Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications

Istanbullu, H. and Ahmed, S. and Sheraz, M.A. and Rehman, I.U. (2013) Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications. Biomed Research International, 2013. ISSN 2314-6133

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Abstract

The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1: 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1: 2 to 1: 5 ratios, respectively. © 2013 Hilal Istanbullu et al.

Item Type:
Journal Article
Journal or Publication Title:
Biomed Research International
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400
Subjects:
?? POLYMERPOLYURETHANSOLVENTTETRAHYDROFURANTOLFENAMIC ACIDANTHRANILIC ACID DERIVATIVEARTICLEDIFFERENTIAL SCANNING CALORIMETRYDRUG SYNTHESISINFRARED SPECTROSCOPYSCANNING ELECTRON MICROSCOPYX RAY DIFFRACTIONCHEMISTRYDRUG DELIVERY SYSTEMSYNTHESISCALORIMETRY, DI ??
ID Code:
132932
Deposited By:
Deposited On:
16 Apr 2019 16:05
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Sep 2023 01:55