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Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies against Parasitic Protozoa.

Grant, Karen M. (2008) Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies against Parasitic Protozoa. Current Pharmaceutical Design, 14 (9). pp. 917-924. ISSN 1873-4286

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Abstract

Protozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of targeting key regulators of the parasite cell cycle will be discussed, paying particular attention to three families of protein kinases: Cyclin-dependent kinases, glycogen synthase kinases and Aurora kinases. This review shall outline their identification, which has been greatly accelerated by the availability of parasite genome data, their validation as bona fide regulators of the parasite cell cycle and current data on the availability and anti-parasite activity of inhibitors.

Item Type: Article
Journal or Publication Title: Current Pharmaceutical Design
Uncontrolled Keywords: Cyclin-dependent kinase Glycogen synthase kinase Aurora kinase cell cycle Trypanosoma Leishmania Plasmodium
Subjects: R Medicine > RM Therapeutics. Pharmacology
Departments: Faculty of Health and Medicine > Medicine
ID Code: 13103
Deposited By: Dr Karen Grant
Deposited On: 05 Sep 2008 11:14
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:05
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/13103

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