Hathout, Rania Mohammed Hafez Mohammed and Hardy, John George and Metwally, AbdelKader and El-Ahmady, Sherweit and Metwally, Eman and Ghonim, Noha and Bayoumy, Salma and Erfan, Tarek and Ashraf, Rosaline and Fadel, Maha and El-Kholy, Abdullah (2018) Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. Journal of Drug Delivery Science and Technology. ISSN 1773-2247
1_s2.0_S1773224718306208_main.pdf - Accepted Version
Available under License Creative Commons Attribution-NonCommercial-NoDerivs.
Download (1MB)
Abstract
We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).