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The Hippocampus and Delayed Recall: Bigger is not Necessarily Better?

Foster, Jonathan K. and Meikle, Andrew and Goodson, Gregory and Mayes, Andrew R. and Howard, Matthew and Sunram, Sandra I. and Cezayirilli, Enis and Roberts, Neil (1999) The Hippocampus and Delayed Recall: Bigger is not Necessarily Better? Memory, 7 (5/6). pp. 715-732. ISSN 0965-8211

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Abstract

Healthy young female participants were tested on a measure of delayed verbal recall and then received volumetric Magnetic Resonance Imaging (MRI) scans. The analysis of the MRI scans focused on the volume of the hippocampus. Left hippocampal volume was negatively associated with the level of delayed verbal recall performance. This relationshipwas confirmed in further testing. This finding is consistent with a previous report of a similar relationship in healthy elderly individuals, but not in patients with Alzheimer’s disease, in whom the opposite relationship was observed. An explanation of these findings in terms of impaired neural pruning of the hippocampus is advanced, whereby insufficient pruning of the hippocampus during childhood and adolescence (following adequate growth) may lead to reduced mnemonic efficiency.

Item Type: Article
Journal or Publication Title: Memory
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Departments: Faculty of Science and Technology > Psychology
ID Code: 11176
Deposited By: Dr Sandra I. Sunram-Lea
Deposited On: 04 Aug 2008 15:24
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 14:58
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/11176

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