The Effects of Potassium Channel Blockers on Progesterone-Induced Suppression of Rat Portal Vein Contractility.

Mukerji, M. S. and Leathard, H. L. and Huddart, Henry (2000) The Effects of Potassium Channel Blockers on Progesterone-Induced Suppression of Rat Portal Vein Contractility. Journal of Pharmacy and Pharmacology, 52 (8). pp. 983-990. ISSN 0022-3573

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Abstract

The suppression of contractility of rat portal vein caused by progesterone appears to be due to the potassium (K+) channel opening effect of this hormone. The identity of the specific K+ channels involved has been investigated using a variety of K+ channel blockers. Incubation with 100 nM iberiotoxin antagonised the progesterone-induced inhibition of spontaneous and 20 mM K+-induced phasic activity of the portal vein such that the contractions resembled those of the non-progesterone, non-iberiotoxin control tissues treated with the corresponding solvent vehicles. Incubation with barium chloride (20 and 100 M), 4-aminopyridine (1 mM), tetraethylammonium chloride (1 mM), glibenclamide (1 M) or apamin (1 M) did not, however, have the same antagonistic effect. These results suggest that progesterone’s selective suppression of rat portal vein contractility is mediated by the opening of BKCa channels.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Pharmacy and Pharmacology
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qh301
Subjects:
?? PHARMACEUTICAL SCIENCEPHARMACOLOGYQH301 BIOLOGY ??
ID Code:
10881
Deposited By:
Deposited On:
25 Jul 2008 13:11
Refereed?:
Yes
Published?:
Published
Last Modified:
17 Sep 2023 00:12