Lancaster EPrints

The Effects of Potassium Channel Blockers on Progesterone-Induced Suppression of Rat Portal Vein Contractility.

Mukerji, M. S. and Leathard, H. L. and Huddart, Henry (2000) The Effects of Potassium Channel Blockers on Progesterone-Induced Suppression of Rat Portal Vein Contractility. Journal of Pharmacy and Pharmacology, 52 (8). pp. 983-990. ISSN 0022-3573

Full text not available from this repository.

Abstract

The suppression of contractility of rat portal vein caused by progesterone appears to be due to the potassium (K+) channel opening effect of this hormone. The identity of the specific K+ channels involved has been investigated using a variety of K+ channel blockers. Incubation with 100 nM iberiotoxin antagonised the progesterone-induced inhibition of spontaneous and 20 mM K+-induced phasic activity of the portal vein such that the contractions resembled those of the non-progesterone, non-iberiotoxin control tissues treated with the corresponding solvent vehicles. Incubation with barium chloride (20 and 100 M), 4-aminopyridine (1 mM), tetraethylammonium chloride (1 mM), glibenclamide (1 M) or apamin (1 M) did not, however, have the same antagonistic effect. These results suggest that progesterone’s selective suppression of rat portal vein contractility is mediated by the opening of BKCa channels.

Item Type: Article
Journal or Publication Title: Journal of Pharmacy and Pharmacology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 10881
Deposited By: Mr Richard Ingham
Deposited On: 25 Jul 2008 14:11
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 20:19
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/10881

Actions (login required)

View Item