Mukerji, M. S. and Leathard, H. L. and Huddart, Henry (2000) The Effects of Potassium Channel Blockers on Progesterone-Induced Suppression of Rat Portal Vein Contractility. Journal of Pharmacy and Pharmacology, 52 (8). pp. 983-990. ISSN 0022-3573Full text not available from this repository.
The suppression of contractility of rat portal vein caused by progesterone appears to be due to the potassium (K+) channel opening effect of this hormone. The identity of the specific K+ channels involved has been investigated using a variety of K+ channel blockers. Incubation with 100 nM iberiotoxin antagonised the progesterone-induced inhibition of spontaneous and 20 mM K+-induced phasic activity of the portal vein such that the contractions resembled those of the non-progesterone, non-iberiotoxin control tissues treated with the corresponding solvent vehicles. Incubation with barium chloride (20 and 100 M), 4-aminopyridine (1 mM), tetraethylammonium chloride (1 mM), glibenclamide (1 M) or apamin (1 M) did not, however, have the same antagonistic effect. These results suggest that progesterone’s selective suppression of rat portal vein contractility is mediated by the opening of BKCa channels.
|Journal or Publication Title:||Journal of Pharmacy and Pharmacology|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
|Deposited By:||Mr Richard Ingham|
|Deposited On:||25 Jul 2008 14:11|
|Last Modified:||09 Apr 2014 20:19|
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