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Lysine metabolism in higher plants.

Azevedo, R. A. and Lea, P. J. (2001) Lysine metabolism in higher plants. Amino Acids, 20 (3). pp. 261-279. ISSN 0939-4451

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Abstract

The essential amino acid lysine is synthesised in higher plants via a pathway starting with aspartate, that also leads to the formation of threonine, methionine and isoleucine. Enzyme kinetic studies and the analysis of mutants and transgenic plants that overaccumulate lysine, have indicated that the major site of the regulation of lysine synthesis is at the enzyme dihydrodipicolinate synthase. Despite this tight regulation, there is strong evidence that lysine is also subject to catabolism in plants, specifically in the seed. The two enzymes involved in lysine breakdown, lysine 2-oxoglutarate reductase (also known as lysine α-ketoglutarate reductase) and saccharopine dehydrogenase exist as a single bifunctional protein, with the former activity being regulated by lysine availability, calcium and phosphorylation/dephosphorylation.

Item Type: Article
Journal or Publication Title: Amino Acids
Uncontrolled Keywords: Amino acids - Aspartate kinase - Aspartate - Lysine synthesis - Lysine 2-oxoglutarate reductase - Methionine - Threonine
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 10775
Deposited By: Mr Richard Ingham
Deposited On: 24 Jul 2008 09:39
Refereed?: Yes
Published?: Published
Last Modified: 18 Sep 2013 15:58
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/10775

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