Barber, N. J. and Zhang, X. and Zhu, G. and Pramanik, R. and Barber, J. A. and Martin, Francis L. and Morris, J. D. H. and Muir, G. H. (2006) Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases, 9 (4). pp. 407-413. ISSN 1365-7852Full text not available from this repository.
Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.
|Journal or Publication Title:||Prostate Cancer and Prostatic Diseases|
|Uncontrolled Keywords:||prostate cancer ; lycopene ; diet|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
|Deposited By:||Dr Francis L Martin|
|Deposited On:||09 Jul 2008 09:14|
|Last Modified:||17 Sep 2013 10:47|
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