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Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.

Barber, N. J. and Zhang, X. and Zhu, G. and Pramanik, R. and Barber, J. A. and Martin, Francis L. and Morris, J. D. H. and Muir, G. H. (2006) Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases, 9 (4). pp. 407-413. ISSN 1365-7852

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Abstract

Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.

Item Type: Article
Journal or Publication Title: Prostate Cancer and Prostatic Diseases
Uncontrolled Keywords: prostate cancer ; lycopene ; diet
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 10177
Deposited By: Dr Francis L Martin
Deposited On: 09 Jul 2008 09:14
Refereed?: Yes
Published?: Published
Last Modified: 17 Sep 2013 10:47
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/10177

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