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Volumetric neural correlates of antisaccade eye movements in first-episode psychosis.

Ettinger, Ulrich and Kumari, Veena and Chitnis, Xavier A. and Corr, Philip J. and Crawford, Trevor J. and Fannon, Dominic G. and O’Ceallaigh, Séamus and Sumich, Alex L. and Doku, Victor C. and Sharma, Tonmoy (2004) Volumetric neural correlates of antisaccade eye movements in first-episode psychosis. American Journal of Psychiatry, 161 (10). pp. 1918-1921. ISSN 1535-7228

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OBJECTIVE: The authors investigated the structural brain correlates of antisaccade performance. METHOD: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. RESULTS: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. CONCLUSIONS: These findings point to altered structure-function relationships in first-episode psychosis.

Item Type: Article
Journal or Publication Title: American Journal of Psychiatry
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Departments: Faculty of Science and Technology > Psychology
ID Code: 10017
Deposited By: Mrs Karen Gerrard
Deposited On: 25 Jun 2008 14:40
Refereed?: Yes
Published?: Published
Last Modified: 20 Aug 2016 01:02
Identification Number:

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